Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines
نویسندگان
چکیده
منابع مشابه
Fungal Keratitis Caused by Aspergillus Species
Background: Fungal keratitis (keratomycosis) is the inflammation of the eye's cornea that results from fungal infection. Case Report: A 29-yrs-old female patient who wears contact lenses presented with ocular pain, redness and blurred vision. Following failures with previous antibacterial topical treatment, a corneal scraping was sent to the mycology laboratory. Fungal elements have been demons...
متن کاملConfocal microscopy of Aspergillus fumigatus keratitis.
AIM To use a confocal microscope to characterise the treated and untreated courses of fungal keratitis. METHODS In the first experiment, Aspergillus fumigatus stromal keratitis was produced in both eyes of seven New Zealand white rabbits. In the second experiment, keratitis was induced in right eyes of 20 rabbits. Group 1 rabbits were treated with topical fluconazole, group 2 rabbits received...
متن کاملPattern recognition receptors in fungal immunity.
Over the last decade, invasive fungal infections have emerged as a growing threat to human health worldwide and novel treatment strategies are urgently needed. In this context, investigations into host-pathogen interactions represent an important and promising field of research. Antigen presenting cells such as macrophages and dendritic cells are strategically located at the frontline of defenc...
متن کاملAspergillus fumigatus keratitis following intracorneal ring segment implantation
BACKGROUND Fungal keratitis has been rarely reported following intracorneal ring segment (ICRS) inmplantation. This paper aims to report a case of fungal keratitis with aspergillus fumigatus following ICRS implantation for correction of keratoconus. METHODS A retrospective chart review was done. Data including demographics, clinical history and presentation, microbiological analysis as well a...
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Acute kidney injury (AKI) is a leading cause of chronic kidney disease. Proximal tubules are considered to be the primary origin of pathogenic inflammatory cytokines in AKI. However, it remains unclear whether other cell types, including collecting duct (CD) cells, participate in inflammatory processes. The transcription factor GATA2 is specifically expressed in CD cells and maintains their cel...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2021
ISSN: 1552-5783
DOI: 10.1167/iovs.62.3.38